Highly stable and soluble bis-aqua Gd, Nd, Yb complexes as potential bimodal MRI/NIR imaging agents.
نویسندگان
چکیده
A tripodal ligand based on the 8-hydroxyquinolinate binding unit yields a soluble and highly stable bis-hydrated Gd(3+) complex in water (pGd = 19.2(3)) with relaxivity change in the pH range 4.5-7.4 and Nd(3+), Yb(3+) analogues with sizeable NIR emission upon excitation at 370 nm providing a new architecture for the development of bimodal agents.
منابع مشابه
Preparation and characterization of ZnS:Tb,Gd and ZnS:Er,Yb,Gd nanoparticles for bimodal magnetic-fluorescent imaging.
As bimodal magnetic-fluorescent imaging agents, the preparation of ZnS:Tb,Gd and ZnS:Er,Yb,Gd nanoparticles via a facile homogeneous precipitation method is reported. The results show that these nanoparticles are almost spherical in shape with a diameter of 100-200 nm approximately and a major phase of wurtzite-structured ZnS. The products can successfully label the human hepatocellular carcino...
متن کاملPyridine-based lanthanide complexes: towards bimodal agents operating as near infrared luminescent and MRI reporters.
We report two prototype Ln(3+) complexes that address requirements for both MRI and luminescence imaging and we demonstrate that the presence of two H(2)O molecules bound to the Ln(3+), beneficial for MRI applications of the Gd(3+) analogue, is not a major limitation for the development of NIR luminescent agents.
متن کاملBimodal magnetic resonance imaging-computed tomography nanoprobes: A Review
Bimodal imaging combines two imaging modalities in order to benefit from their advantages and compensate the limitations of each modality. This technique could accurately detect diseases for diagnostic purposes. Nanoparticles simultaneously offer diagnostic data via various imaging modalities owing to their unique properties. Moreover, bimodal nanoprobes could be incorporated into theranostic s...
متن کاملHighly luminescent lanthanide complexes with novel bis-β-diketone ligand: synthesis, characterization and photoluminescent properties.
A biphenyl-linked bis-β-diketone ligand, 3,3'-bis(3-phenyl-3-oxopropanol)biphenyl (BPB) has been prepared for the syntheses of a series of dinuclear lanthanide complexes. The ligand bears two benzoyl β-diketonate sites linked by a 3,3'-biphenyl spacer. Reaction of the doubly negatively charged bis-bidenate ligand with lanthanide ions forms triple-stranded dinuclear complexes Ln(2)(BPB)(3) (Ln=N...
متن کاملMultifunctional nanomesoporous materials with upconversion (in vivo) and downconversion (in vitro) luminescence imaging based on mesoporous capping UCNPs and linking lanthanide complexes.
A series of new multifunctional nanomesoporous materials based on upconversion nanophosphors NaYF4:Yb,Tm@NaGdF4 (UCNPs) and lanthanide complexes were designed and synthesized through mesoporous capping UCNPs nanophosphors and linking lanthanide (Ln) complexes. The obtained UCNPs@mSiO2-Ln(dbm)4 (Ln = Eu, Sm, Er, Nd, Yb) materials can achieve downconversion and upconversion luminescence to show m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Dalton transactions
دوره 39 40 شماره
صفحات -
تاریخ انتشار 2010